Alessio Fasano continues to lead the charge with the latest research on the connection between “leaky-gut” and all autoimmune diseases. It won’t be easy to create what really is a “Paradigm Shift” in the medical world but this is the kind of serious science we need to get there. What Fasano does here is take the next step in not only showing how leaky gut is behind these diseases, but that it is possible to heal from these diseases by repairing leaky gut.
Chris Kresser in his latest article & podcast – Can Autoimmune Disease Be Prevented And Reversed? http://chriskresser.com/rhr-can-autoimmune-disease-be-prevented-and-reversed discusses Fasano’s article. Worth listening to!
Mucosal Biology Research Center, University of Maryland School of Medicine, 20 Penn Street HSF II Building, Room S345, Baltimore, MD, 21201, USA, firstname.lastname@example.org.
Autoimmune diseases are characterized by tissue damage and loss of function due to an immune response that is directed against specific organs. This review is focused on the role of impaired intestinal barrier function on autoimmune pathogenesis. Together with the gut-associated lymphoid tissue and the neuroendocrine network, the intestinal epithelial barrier, with its intercellular tight junctions, controls the equilibrium between tolerance and immunity to non-self antigens. Zonulin is the only physiologic modulator of intercellular tight junctions described so far that is involved in trafficking of macromolecules and, therefore, in tolerance/immune response balance. When the zonulin pathway is deregulated in genetically susceptible individuals, autoimmune disorders can occur. This new paradigm subverts traditional theories underlying the development of these diseases and suggests that these processes can be arrested if the interplay between genes and environmental triggers is prevented by re-establishing the zonulin-dependent intestinal barrier function. Both animal models and recent clinical evidence support this new paradigm and provide the rationale for innovative approaches to prevent and treat autoimmune diseases.