Home > Uncategorized > Leaky Gut and Autoimmune Diseases

Leaky Gut and Autoimmune Diseases

 Alessio Fasano continues to lead the charge with the latest research on the connection between  “leaky-gut” and all autoimmune diseases. It won’t be easy to create what really is a “Paradigm Shift” in the medical world but this is the kind of serious science we need to get there. What Fasano does here is take the next step in not only showing how leaky gut is behind these diseases, but that it is possible to heal from these diseases by repairing leaky gut.

AbstractFull Study

Chris Kresser in his latest article & podcast – Can Autoimmune Disease Be Prevented And Reversed? http://chriskresser.com/rhr-can-autoimmune-disease-be-prevented-and-reversed discusses Fasano’s article. Worth listening to!

Mucosal Biology Research Center, University of Maryland School of Medicine, 20 Penn Street HSF II Building, Room S345, Baltimore, MD, 21201, USA, afasano@mbrc.umaryland.edu.


Autoimmune diseases are characterized by tissue damage and loss of function due to an immune response that is directed against specific organs. This review is focused on the role of impaired intestinal barrier function on autoimmune pathogenesis. Together with the gut-associated lymphoid tissue and the neuroendocrine network, the intestinal epithelial barrier, with its intercellular tight junctions, controls the equilibrium between tolerance and immunity to non-self antigens. Zonulin is the only physiologic modulator of intercellular tight junctions described so far that is involved in trafficking of macromolecules and, therefore, in tolerance/immune response balance. When the zonulin pathway is deregulated in genetically susceptible individuals, autoimmune disorders can occur. This new paradigm subverts traditional theories underlying the development of these diseases and suggests that these processes can be arrested if the interplay between genes and environmental triggers is prevented by re-establishing the zonulin-dependent intestinal barrier function. Both animal models and recent clinical evidence support this new paradigm and provide the rationale for innovative approaches to prevent and treat autoimmune diseases.

  1. December 8, 2011 at 3:35 pm

    Thanks for posting this! A really interesting article, indeed.

  2. December 16, 2011 at 7:26 pm

    Excellent work and posts Alan!! Thanks for your work!! G

  3. January 6, 2012 at 6:54 am

    In women, especially with thyroid disease which is also known as HASHIMOTO S AUTOIMMUNE THYROIDITIS may have more hair loss.

  4. January 7, 2012 at 1:22 am

    Thank you so much regarding giving everyone an update on this subject on your site. Please know that if a fresh post appears or when any alterations occur about the current post, I would be considering reading a lot more and learning how to make good using of those strategies you write about. Thanks for your efforts and consideration of other folks by making this site available.

  5. Sebastian Clausin
    January 12, 2012 at 9:08 am

    Thank you for posting this! How do I get in contact with you, do you have an e-mail?

  1. December 8, 2011 at 3:33 pm

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